1. Home ›
  2. Research

Research

Hexagonal cells labeled with various research topics surrounding 'Genetic Crosses' at the center. Cells labeled in blue, green, and red include topics such as 'Parasite Fitness,' 'CRISPR Editing,' 'Bulk Segregant Analysis,' 'Gametocyte Work,' 'AAT1,' 'PPQ-R,' 'ART-R,' 'Parasite Nutrition,' and 'Transcriptomics.' Each cell represents a specific area of research related to genetic and molecular biology.

Our research integrates diverse focus areas—including genetics, molecular biology, systems biology, and bioinformatics—to address critical challenges in parasite biology and drug resistance mechanisms. Utilizing experimental genetic crosses facilitated by technologies like the human-liver chimeric mouse model (FRG huHep/huRBC mouse), we examine genetic determinants, pathways, and phenotypic variations such as transcriptomic, proteomic, and metabolomic profiles.

By understanding the factors that drive artemisinin and piperaquine resistance in Plasmodium falciparum, we aim to identify strategies to counteract the evolution of drug resistance. Supported by collaborative efforts across our research projects and cores, this work contributes to broader efforts in developing effective solutions for malaria control and provides insights that may inform approaches against other drug-resistant pathogens.